Authors
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Current Limitations of CAR T-Cell Therapy in Multiple Myeloma: Muhamed Baljevic, MDThe assistant professor from University of Nebraska Medical Center discussed the current limitations of CAR T-cell therapy in multiple myeloma.
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Selecting AAV Manufacturing PlatformsThe chief scientific officer and chief medical officer of Ultragenyx Gene Therapy discussed the company’s future research in gene therapies.
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Francesca Barone, MD, PhD, on Viral Immunotherapy for Glioma, Prostate CancerThe chief scientific officer at Candel Therapeutics discussed progress in investigations with CAN-3110 and CAN-2409.
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Autologous HSCT's Role in the Mantle Cell Lymphoma Treatment LandscapeAutologous hematopoietic stem-cell transplantation maintained its long-term efficacy over interferon alfa in patients with mantle cell lymphoma.
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John Ligon, MD, on Fertility Outcomes in Patients Who Have Received CAR-TThe assistant professor in the department of pediatrics at the University of Florida College of Medicine discussed also discussed the need to set standard guidelines regarding potential fertility issues for CAR-T treatment.
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Novel Therapies in Heavily Pretreated Multiple Myeloma: Omar Nadeem, MDThe physician from the Dana-Farber Cancer Institute discussed the uptake of novel therapies in heavily pretreated multiple myeloma.
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Craig M. McDonald, MD, on Safety and Efficacy of DMD Cell TherapyThe principal investigator of the HOPE-2 trial discussed safety and efficacy of Capricor’s CAP-1002.
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Gene Therapy Updates in Neuromuscular DiseasesCrystal Proud, MD, outlines advances in technology and research in neuromuscular diseases.
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RGX-314 Gene Therapy Efficacious in Wet AMD: Robert L. Avery, MDThe chief executive officer of California Retina Consultants discussed the positive results of RGX-314 gene therapy in wet AMD.
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Jennifer Gori, PhD, on the Potential of a Prime Editing Approach in Treating Chronic Granulomatous DiseaseThe vice president of research at Prime Medicine discussed a preclinical study on a novel autologous HSCT treatment that was presented at ASGCT’s 2023 annual meeting.
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Maria Pia Morelli, MD, PhD, on Adapting ctDNA and MRD Negativity Into Solid Tumor Cell Therapy ResearchThe assistant professor at MD Anderson Cancer Center discussed a trial she is leading at MD Anderson with NK cells and cetuximab in colorectal cancer.
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Terese Hammond, MD, on Evolving Treatments for ARDS and More With ImmunotherapyThe director of the CCU/ICU at Saint John’s Health Center discussed a possible more collaborative approach to treating patients in the future.
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Robert Wenham, MD, MS, FACS, On Assessing FSHR-CAR-T Therapy in Ovarian CancerThe chair of gynecologic oncology at Moffitt Cancer Center gave an overview of a phase 1 trial being conducted at Moffitt Cancer Center.
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Yara Abdou, MD, on the Advantages of CAR Macrophages in Solid TumorsThe assistant professor of oncology at UNC School of Medicine discussed the first-in-human study being conducted with CT-0508.
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Uttam Rao, MD, MBA, on Comparing Conditioning Regimens for CAR-TThe transplant physician at St. David's South Austin Medical Center of the Sarah Cannon Transplant and Cell Therapy Network discussed a real-world study comparing bendamustine against fludarabine and cyclophosphamide.
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Brett Kopelan, MA, and Heather Fullmer on the Potential Impact of Gene Therapy on Epidermolysis Bullosa’s Treatment LandscapeIn observance of Epidermolysis Bullosa Awareness Week, the debra of America representatives discussed unmet needs for the patient population and the approval of the first EB gene therapy.
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TJ Cradick, PhD, on A Potential Cure for HIV With EBT-101The chief scientific officer of Excision BioTherapeutics discussed the phase 1/2 clinical trial of the CRISPR gene editing therapy.
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Future Research With Car T-Cell Therapy in Multiple Myeloma: Adam Sperling, MD, PhDThe physician at the Dana-Farber Cancer Institute and instructor in medicine at Harvard Medical School discussed future research with CAR T-cell therapy in multiple myeloma.
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Rachel Lynn, PhD, on Reprogramming Cell Therapies to Combat ExhaustionThe associate director of research at Lyell Immunopharma discussed the company’s programs and newest technologies aimed at solid tumors.
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Frederick “Eric” Arnold, PhD, on Examining Genetic Variants for PolyadenylationThe postdoctoral scholar at University of California – Irvine discussed research aiming to link genetic variants and neurodegeneration.
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James Beck, PhD, on Laying Groundwork for Gene Therapy in Parkinson DiseaseThe chief scientific officer and senior vice president of the Parkinson’s Foundation discussed remaining research and education needs to support the future of genetic medicines.
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Matthew Frank, MD, PhD, on Eliciting Response in Pretreated LBCL With CD22-Targeted CAR T CellsA presentation at EHA 2023 showed important safety and efficacy data with CD22 CAR T cells in heavily pretreated patients with large B-cell lymphoma and pointed to how this may shed light on sequencing in this field.
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Developing Nonviral Gene Therapy for Hemophilia ABrent Warner, president, gene therapy, Poseida Therapeutics, discussed data on the preclinical P-FVIII-101 presented at ASH 2022.
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Expanding the Use of CAR T Therapy With shRNAThe chief executive and chief medical officers of Celyad Oncology discussed the company’s future research and plans.
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Gregory W. Roloff, MD, on Further Investigation With Sequencing and CAR T in B-ALLThe chief hematology/oncology fellow at University of Chicago discussed further research his center is working on with cell therapy in B-cell acute lymphoblastic leukemia.
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Jonas Wang, PhD, on the Advantages of Cord Blood-Derived Stem Cells in Regenerative MedicineFor World Cord Blood Day, the chairman and president of StemCyte discussed his thoughts on the importance of cord blood stem cells for the healthcare community.
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Deepak L. Bhatt, MD, MPH, MBA, on Encouraging Data With Gene Editing for HypercholesteremiaThe director of the Mount Sinai Fuster Heart Hospital shared his optimism on data seen so far with VERVE-101.
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Monitoring and Support for Patients Receiving CAR T-Cell TherapyExperts discuss providing supportive care to patients receiving CAR T-cell therapy.
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Stefanie Bailey, PhD, on the Role of Interferon-γ in CAR T-Cell TherapyThe research fellow from Harvard Medical School discussed blocking IFNg as a potential approach to reduce toxicities.
