Dr. Lekakis on Real-World Data With CAR T-Cell Therapy in Lymphoma

Video

Lazaros John Lekakis, MD, associate professor of clinical medicine, Sylvester Comprehensive Cancer Center, University of Miami Health System, discusses real-world data with CAR T-cell therapy from the 2018 ASH Annual Meeting.

Lazaros John Lekakis, MD, associate professor of clinical medicine, Sylvester Comprehensive Cancer Center, University of Miami, discusses real-world data with CAR T-cell therapy from the 2018 ASH Annual Meeting.

The real-world data for the use of axicabtagene ciloleucel (axi-cel; Yescarta) came as a surprise to some physicians, says Lekakis. A lot of people in the community thought the ZUMA-1 trial data would not be reproducible in practice as there were very strict exclusion criteria for the study. However, the real-world data with over 200 patients showed a complete response rate that was consistent with the data from the ZUMA-1 trial.

Moreover, it was not the only trial that demonstrated those results in a real-world setting, says Lekakis. Taken collectively, these data show that approximately 37% of patients had no evidence of disease at the time of data cutoff. These patients are most likely cured because very few relapses happen after a 6-month cutoff, adds Lekakis.

Recent Videos
Reena Sharma, MD, an adult metabolic consultant at Salford Royal Hospital
Mark Hamilton, MD, PhD, a hematology-oncology and bone marrow transplant (BMT) cell therapy fellow at Stanford University
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Sarah Larson, MD, the medical director of the Immune Effector Cell Therapy Program in the Division of Hematology/Oncology at David Geffen School of Medicine at University of California, Los Angeles (UCLA)
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
Georg Schett, MD, vice president research and chair of internal medicine at the University of Erlangen – Nuremberg
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
© 2025 MJH Life Sciences

All rights reserved.