Dr. Park on Using CD19-Targeted CAR T Cells as Treatment for ALL

Video

Jae H. Park, MD, attending physician, Leukemia Service, Memorial Sloan Kettering Cancer Center, discusses a trial presented at the 2014 ASH Annual Meeting that explored CD19-targeted T cells as treatment for patients with relapsed, refractory B- cell ALL.

Jae H. Park, MD, attending physician, Leukemia Service, Memorial Sloan Kettering Cancer Center, discusses a trial presented at the 2014 ASH Annual Meeting that explored CD19-targeted T cells as treatment for patients with relapsed, refractory B- cell ALL.

Park says these patients have a very poor prognosis in overall survival, with previous studies showing an overall survival of less than 10%.

In order to improve the survival of these patients, researchers have modified patients’ own T cells to express CAR to target CD19, which is expressed in all patients with B-Cell ALL, Park says.

Using these modified CAR T cells, researchers have treated up to 33 patients. Of the 27 patients that were evaluable for response, 24 patients achieved complete response for a CR rate of 80%, Park says. Those patients that achieved a complete response, the majority of them were MRD-, which proves that the treatment is providing a deep response, despite that these are very high-risk patients.

<<<

View more from the 2014 ASH Annual Meeting

Recent Videos
Tami John, MD
Tami John, MD
Tami John, MD
Matthew Ku, MBBS, FRACP, RACP, FRCPA/RCPA, PhD, an associate professor and the lymphoma stream lead at St Vincent’s Hospital
Saurabh Dahiya, MD, FACP, an associate professor of medicine at Stanford University School of Medicine; as well as clinical director of Cancer Cell Therapy in the Division of Blood and Marrow Transplantation and Cell Therapy at Stanford Medicine
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Laura Aguilar MD, PhD, the chief medical officer of Diakonos Oncology
Jamie Jacobs, PhD, the program director of the center for psychiatric oncology & behavioral sciences at Mass General Cancer Center
Related Content
© 2025 MJH Life Sciences

All rights reserved.