Carlos R. Bachier, MD

Carlos R. Bachier, MD, director, blood and marrow transplant research, Sarah Cannon Research Institute, discusses the investigational CAR T-cell therapy lisocabtagene maraleucel (liso-cel) in diffuse large B-cell lymphoma (DLBCL).

A biologics license application is currently under priority review by the FDA for liso-cel, a CD19-directed CAR T-cell product, says Bachier. 

the 2020 European Hematology Association Annual Congress

, findings from a study evaluating the safety and efficacy of liso-cel in patients who were monitored in the outpatient setting in the TRANSCEND NHL 001, TRANSCEND OUTREACH-007, and TRANSCEND-PILOT-017006 trials were presented.

Notably, CAR T-cell therapy is associated with a specific set of adverse effects (AEs), including cytokine release syndrome and neurologic toxicities, explains Bachier. However, liso-cel appears to have a relatively low incidence of late-onset AEs compared with other CAR T-cell products. 

As such, liso-cel may have utility as an outpatient therapy for patients with DLBCL pending further investigation, concludes Bachier.

Videos

Carlos R. Bachier, MD, discusses the investigational CAR T-cell therapy lisocabtagene maraleucel in diffuse large B-cell lymphoma.








Dr. Bachier on the Potential Benefits of Liso-Cel in DLBCL 

Carlos R. Bachier, MD, program director of Sarah Cannon Center for Blood Cancer, Sarah Cannon Research Institute, discusses the relationship between chimeric antigen receptor (CAR) T-cell therapy and stem cell transplant.

The excitement with CAR T-cell therapy and T-cell receptor immune cells is very exciting, and has a relationship to the advancements being made with stem cell transplant, says Bachier. With the recent advances in cellular therapies, investigators are interested in finding whether there is a bridge between CAR T-cell therapy and stem cell transplant.

Bachier wonders if it is possible to get patients into deep remission with CAR T cells or immune effector cells so that stem cell transplant can be more effective. The concept is currently being developed and tested in acute lymphocytic leukemia, where there is still an incidence of relapse after CAR T-cell therapy.

Carlos R. Bachier, MD, program director of Sarah Cannon Center for Blood Cancer, Sarah Cannon Research Institute, discusses the relationship between chimeric antigen receptor (CAR) T-cell therapy and stem cell transplant.
 

Carlos R. Bachier, MD

Articles

Dr. Bachier on the Potential Benefits of Liso-Cel in DLBCL

Dr. Bachier Discusses CAR T-Cell Therapy and Stem Cell Transplant