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Jane de Lartigue, PhD

Articles

TILs, the Ultimate in Personalized Immunotherapy, Move Closer to Market

November 24, 2020

November 24, 2020 - Until now, the field of cell-based immunotherapy has been dominated by chimeric antigen receptor (CAR) T cells, with groundbreaking FDA approvals for 3 drugs across several types of hematologic malignancies. In solid tumors, however, CAR T-cell therapies have yet to gain ground.

CD22 Emerges as CAR T-Cell Therapy Target

October 17, 2018

Although CD19 has proved to be an attractive and effective target for chimeric antigen receptor T-cell therapies in hematologic malignancies, a significant subset of patients treated with this groundbreaking form of immunotherapy eventually relapse.

Targeting Mitosis: First Polo-Like Kinase Inhibitor Moves Closer to FDA Approval

September 25, 2014

The concept of targeting mitotic cell division to halt the progression of rapidly dividing cancer cells has long been a staple of oncology therapy, yet chemotherapy agents that are the prime examples of this approach are nonselective in their action and can kill normal and malignant cells alike.

MSK's CAR Trials Halted Temporarily Amid Safety Review

April 09, 2014

Five early-phase clinical trials exploring chimeric antigen receptor (CAR) T-cell therapy have been suspended temporarily in response to the deaths of 2 patients with adult B-cell acute lymphoblastic leukemia