More Data Supports Approval as Lifileucel Review for Melanoma Pushed Back
The new PDUFA date of lifileucel is set for Februrary 24, 2024.
Kedar Kirtane, MD, on CAR T-Cell Agent A2B530 and Its Unique Approach to Solid Tumors
The assistant member in the Department of Head and Neck-Endocrine Oncology at Moffitt Cancer Center spoke about A2B530's mechanism of action and how it could represent a leap forward in the application of CAR T-cell agents for patients with solid tumors.
Harnessing a Unique Approach With A2B530 to Bring CAR T Treatment to Solid Tumors
The BASECAMP-1 clinical trial will aim to find patients with advanced solid tumors who are good candidates for the subsequent EVEREST trial.
Bringing HLA-A*02-directed CAR T to Solid Tumor Care With the EVEREST-1 Trial
Diane M. Simeone, MD, discussed the phase 1/2 EVEREST-1 trial, which seeks to assess the novel CAR T-cell therapy A2B530 in patients with solid tumors—hopefully progressing one-and-done engineered therapies in this population.
BASECAMP-1: Trial of Novel CAR T-Cell Agent Seeks Patients Eligible for Treatment
Investigators have initiated the BASECAMP-1 trial of investigational agent A2B530 with the hope of identifying patients with advanced solid tumors who will be suitable candidates for treatment in a subsequent trial.
Celularity, Imugene Collaboration to Focus on CAR T in Solid Tumors
The companies will combine Imugene’s CF33-CD19 oncolytic virus and Celularity’s investigational placental-derived CAR T-cell therapy.
Axi-cel Shows Efficacy, Durability, in Relapsed/Refractory Follicular Lymphoma
Henry Chi Hang Fung, MD, from the Fox Chase Cancer Center, discusses axi-cel's potential in relapsed/refractory FL.
C-CAR066 Achieves High Marks in Relapsed/Refractory B-NHL
C-CAR066 exhibited a favorable safety profile and promising efficacy in adult patients with relapsed/refractory B-cell non-Hodgkin lymphoma who failed with prior CD19 CAR T-cell therapy.
Liso-cel Expands CAR T-Cell Options in Lymphoma
Amitkumar Mehta, MD, discusses the safety profile of liso-cel and how it is advancing the relapsed/refractory large B-cell lymphoma treatment paradigm.
Caribou and AbbVie Initiate Development Partnership for CAR T-Cell Products
AbbVie and Caribou Biosciences, Inc have entered into a collaboration and license agreement for the research and development of chimeric antigen receptor T-cell therapeutics.
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