Piers Blombery, MBBS, PhD, on Investigating CAR+ T-Cell Lymphoma After Cilta-Cel

Commentary
Video

The associate professor at Peter MacCallum Cancer Centre discussed case study research from the center and possible contributions to the case.

“It looks there’s a contribution of possibly where the CAR's inserted, into a...premalignantT-cell, in a patient with a potential germline mutation predisposition to developing this malignancy and that appears together to have caused a CAR T uncontrolled lymphoproliferation. There’s always a lot of work to be done and a lot of work we’re doing at the moment to further understand the contribution of all 3 parts but that's where we are at the moment.”

New research out of the Peter MacCallum Cancer Centre in Australia has reported on a case study of the first described case of chimeric antigen receptor (CAR)+ T-cell lymphoma due to lentiviral transduction in a patient with multiple myeloma treated with ciltacabtagene ciloleucel (Carvykti; Janssen, Legend Biotech) in the phase 3 CARTITUDE-4 study (NCT04181827). The research was described in an abstract accepted to the 2023 American Society of Hematology (ASH) Annual Meeting & Exposition, held December 9-12, in San Diego, California, as an online publication.

CGTLive spoke with the abstract’s senior author, Piers Blombery, MBBS, PhD, associate professor, Peter MacCallum Cancer Centre, and head, Wilson Centre for Blood Cancer Genomics, to learn more about the case of CAR+ lymphoma. He described possibly characteristics of the patient that may have lead to the oncogenesis, including a dysregulated PBX2 gene, TET2 clonal hematopoiesis, and a JAK3-activating allele germline mutation, although these are educated guesses. As these findings are based only off of one patient, Blombery stressed that further research is necessary to make definitive conclusions about the case, and that his team is continuing to investigate it.

REFERENCE
Harrison SJ. Nguyen T, Rahman M, et al. CAR+ T-Cell lymphoma post ciltacabtagene autoleucel therapy for relapsed refractory multiple myeloma. Blood (2023): 142; 1. 6939. doi: 10.1182/blood-2023-178806
Recent Videos
Haydar Frangoul, MD, the medical director of pediatric hematology/oncology at Sarah Cannon Research Institute and Pediatric Transplant and Cellular Therapy Program at TriStar Centennial
David Barrett, JD, the chief executive officer of ASGCT
Georg Schett, MD, vice president research and chair of internal medicine at the University of Erlangen – Nuremberg
David Barrett, JD, the chief executive officer of ASGCT
Bhagirathbhai R. Dholaria, MD, an associate professor of medicine in malignant hematology & stem cell transplantation at Vanderbilt University Medical Center
Caroline Diorio, MD, FRCPC, FAAP, an attending physician at the Cancer Center at Children's Hospital of Philadelphia
R. Nolan Townsend; Sandi See Tai, MD; Kim G. Johnson, MD
Daniela van Eickels, MD, PhD, MPH, the vice president and head of medical affairs for Bristol Myers Squibb’s Cell Therapy Organization
Paul Melmeyer, MPP, the executive vice president of public policy & advocacy at MDA
Related Content
© 2024 MJH Life Sciences

All rights reserved.