Dr. Adusumilli on the Development of CAR T Cells in Solid Tumors

Video

Prasad S. Adusumilli, MD, FACS, discusses the current role of chimeric antigen receptor T-cell therapy as treatment of patients with solid tumors and how this is evolving compared to CAR T cells in hematologic malignancies.

Prasad S. Adusumilli, MD, FACS, deputy chief, Thoracic Surgery, Memorial Sloan Kettering Cancer Center, discusses the current role of chimeric antigen receptor (CAR) T-cell therapy as treatment of patients with solid tumors and how this is evolving compared to CAR T cells in hematologic malignancies.

Investigators are currently translating data from preclinical trials to determine the potential role of CAR T cells in solid tumors. Unlike in the hematologic space, there are several hurdles to overcome in solid tumors that are specific to the solid tumor microenvironment, Adusumilli says.

At this time, investigators are focusing on how to overcome each of the hurdles to determine the role of CAR T-cell therapy in the treatment landscape of solid tumors.

For example, one hurdle to overcome is that T cells are unable to enter the tumor with solid tumors, especially when the T cells are administered intravenously, Adusumilli explains.

<<< 2020 International Congress on Hematologic Malignancies

Recent Videos
Mark Hamilton, MD, PhD, a hematology-oncology and bone marrow transplant (BMT) cell therapy fellow at Stanford University
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Sarah Larson, MD, the medical director of the Immune Effector Cell Therapy Program in the Division of Hematology/Oncology at David Geffen School of Medicine at University of California, Los Angeles (UCLA)
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
Georg Schett, MD, vice president research and chair of internal medicine at the University of Erlangen – Nuremberg
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
© 2025 MJH Life Sciences

All rights reserved.