Dr. Adusumilli on the Development of CAR T Cells in Solid Tumors

Video

Prasad S. Adusumilli, MD, FACS, discusses the current role of chimeric antigen receptor T-cell therapy as treatment of patients with solid tumors and how this is evolving compared to CAR T cells in hematologic malignancies.

Prasad S. Adusumilli, MD, FACS, deputy chief, Thoracic Surgery, Memorial Sloan Kettering Cancer Center, discusses the current role of chimeric antigen receptor (CAR) T-cell therapy as treatment of patients with solid tumors and how this is evolving compared to CAR T cells in hematologic malignancies.

Investigators are currently translating data from preclinical trials to determine the potential role of CAR T cells in solid tumors. Unlike in the hematologic space, there are several hurdles to overcome in solid tumors that are specific to the solid tumor microenvironment, Adusumilli says.

At this time, investigators are focusing on how to overcome each of the hurdles to determine the role of CAR T-cell therapy in the treatment landscape of solid tumors.

For example, one hurdle to overcome is that T cells are unable to enter the tumor with solid tumors, especially when the T cells are administered intravenously, Adusumilli explains.

<<< 2020 International Congress on Hematologic Malignancies

Recent Videos
Daniela van Eickels, MD, PhD, MPH, the vice president and head of medical affairs for Bristol Myers Squibb’s Cell Therapy Organization
Arun Upadhyay, PhD, the chief scientific officer and head of research, development, and Medical at Ocugen
Arun Upadhyay, PhD, the chief scientific officer and head of research, development, and Medical at Ocugen
John Brandsema, MD, a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia
John Brandsema, MD, a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia
Barry J. Byrne, MD, PhD, the chief medical advisor of Muscular Dystrophy Association (MDA) and a physician-scientist at the University of Florida
John Brandsema, MD, a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia
Chun-Yu Chen, PhD, a research scientist at Seattle Children’s Research Institute
William Chou, MD, on Targeting Progranulin With Gene Therapy for Frontotemporal Dementia
© 2024 MJH Life Sciences

All rights reserved.