Dr. Ostertag on Emerging CAR T Product for Myeloma

Video

Eric M. Ostertag, MD, PhD, chief executive officer, Poseida Therapeutics, Inc., discusses an emerging CAR T stem cell memory product for patients with relapsed/refractory multiple myeloma.

Eric M. Ostertag, MD, PhD, chief executive officer, Poseida Therapeutics, Inc., discusses an emerging CAR T stem cell memory product for patients with relapsed/refractory multiple myeloma.

Phase I data for the CAR T stem cell memory product P-BCMA-101 was presented at the 2018 AACR Annual Meeting. A major difference between this product and other CAR T cells is that it was not created using a virus; instead, developers used a technology called DNA transposon. An advantage of this manufacturing technique, Ostertag says, is that it allows researchers to essentially have unlimited cargo capacity. A centyrin is then added to the product instead of a commonly used antibody. Researchers also added a gene that allows for a positive selection. Ostertag says there are data that suggest this translates into a better therapeutic index because it not only kills the tumor, but it also releases cytokines.

The ongoing phase I trial has shown efficacy in 3 patients, including one partial response lasting more than 10 weeks at time of data cutoff.

Related Videos
Dilsher Dhoot, MD, on a Promising Start With Diabetic Retinopathy Gene Therapy RGX-314
J. Andrew Livingston, MD, on Forging Forward With Novel Sarcoma Trials
Shankar Musunuri, PhD, on Gene Modifier Therapy vs Gene Replacement Therapy for IRDs
Pat Furlong, BSN, RN, on the State of Gene Therapy in Muscular Dystrophy
Michael Kelly, PhD, on Continuing Progress With Gene Therapy in Muscular Dystrophy
Thomas McCauley, PhD, on Potential Advantages of Epigenetic Therapy Over Small Molecule, Gene Therapy
Related Content
© 2023 MJH Life Sciences

All rights reserved.