Commentary|Podcasts|December 24, 2025

ImmunoLogic, Bonus Episode: "ASH 2025: Practice-Changers on the Ground and on the Wi‑Fi"

In this bonus episode of ImmunoLogic, the hosts discussed immunotherapy highlights from ASH's annual meeting.

Episode Breakdown

  • 0:00 – Intro
  • 2:16 – PARADIGM Trial in AML
  • 5:41 – Fixed‑duration vs continuous BTK inhibition
  • 14:55 – ctDNA in lymphoma
  • 19:17 – Multitarget CAR-T
  • 25:31 – Secondary T‑cell malignancies after CAR T
  • 29:10 – Combination vs sequencing in follicular lymphoma

We're excited to introduce another episode of the ImmunoLogic video podcast, hosted by Joseph Fraietta, PhD, an assistant professor of microbiology and the director of the Fraietta Lab at the University of Pennsylvania. Fraietta is joined by cohost Janna Minehart, MD, a clinical fellow in oncology (Master of Science Translational Research Program) at the University of Pennsylvania. Our hope is that this show will serve as a critical forum for clinicians, translational researchers, and biotechnology professionals to explore the evolving landscape of immunotherapy. We're seeking to bridge cutting-edge research with practical applications and delve into how immune-based therapies transition from innovative discoveries to transformative patient care solutions.

In this bonus episode, the cohosts discussed immunotherapy highlights from the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, held December 6 to 9, 2025, in Orlando, Florida, which Minehart attended in-person and Fraietta attended virtually. The two spoke about the new data from the PARADIGM trial, buzz on the use of ctDNA for analysis in lymphoma, presentations related to multitarget chimeric antigen receptor T-cell (CAR-T) therapies, new findings related to secondary T‑cell malignancies after CAR-T, and more.

ImmunoLogic is tailored for an audience fluent in the language of medicine and biotechnology, offering data-driven insights while maintaining accessibility. This podcast is an essential resource for those driving the future of immunotherapy.

Interested in cohosting an episode or being a guest? Have feedback to share? If you'd like to get in touch to talk about the show, contact our editorial director, Matt Hoffman: [email protected].

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