Nirav Shah, MD, on New Data on Zamto-cel in DLBCL, Mantle Cell Lymphoma
The associate professor of medicine at Medical College of Wisconsin discussed trials assessing the dual, CD19/CD20-targeting CAR T therapy.
“We're always trying to improve on the current standard of care. I think that right now CD19 is the current standard of care and a great option for patients. We've been looking at this dual targeting approach to see if we can improve upon that, and so I look forward to this trial data maturing for diffuse large B-cell lymphoma, and for mantle cell, right now it’s a single center study, but we think that these data justify a multicenter phase 2 study."
Zamtocabtagene autoleucel (zamto-cel; Miltenyi Biomedicine), a CD19/CD20-targeting chimeric antigen receptor (CAR) T-cell therapy, demonstrated safety and efficacy in updated data from a single center, phase 1/2 prospective trial (NCT04186520) in patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) as well as data from the multicenter, phase 2 DALY II USA trial (NCT04792489) in patients with R/R diffuse large B-cell lymphoma (DLBCL).
Nirav Shah, MD, associate professor of medicine, Medical College of Wisconsin, presented the data in 2 presentations at the 2023 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR, held February 15-18 in Orlando, Florida. CGTLive spoke with Shah to learn more about zamto-cel and the advantages and research being conducted with dual-targeting CAR T therapies. He outlined the data presented and highlighted the favorable safety profile of the therapy.
Click here for more coverage of the 2023 Tandem Meetings.
