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Caroline Seymour


Ibrutinib Boosts the Activity of Second CD19-Directed CAR T-Cell Therapy in Refractory Non-Hodgkin Lymphoma

May 14, 2021

A second treatment with CD19-directed CAR T-cell therapy plus ibrutinib (Imbruvica) following failed prior CD19-directed CAR T-cell therapy and salvage treatment with ibrutinib led to greater efficiency and anti-CD19 CAR T-cell amplification, but also higher grades of cytokine release syndrome and more serious hematologic toxicity in patients with refractory B-cell non-Hodgkin lymphoma.