Dr. Brentjens Discusses Potential for CAR T-Cell Therapy in Solid Tumors

Video

Renier Brentjens, MD, PhD, associate professor, chief, Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, discusses the potential for chimeric antigen receptor therapy (CAR) T-cell therapy in solid tumors.

Renier Brentjens, MD, PhD, associate professor, chief, Cellular Therapeutics Center, Memorial Sloan Kettering Cancer Center, discusses the potential for chimeric antigen receptor therapy (CAR) T-cell therapy in solid tumors.

The success of CD19-targeted CAR T-cell therapy has emboldened investigators to look at other targets on solid tumors—which could be the next big breakthrough, Brentjens says. If successful CAR T-cell therapy would live up to the hype that has surrounded it in the larger medical community.

Brentjens says that the field is no longer solely focused on CD19-directed CAR T-cell therapies in lymphoma and leukemia. Expanding to solid malignancies will be challenging, but doable, Brentjens adds.

Current FDA-approved CAR T-cell therapies include tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (axi-cel; Yescarta), the latter of which targets CD19 in hematologic malignancies.

Newsletter

Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.

Recent Videos
Nathan Yozwiak, PhD, the head of research at the GCTI
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira, and Kilian Guse, PhD, the vice president of genetic medicine platforms at Pacira
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira
Jeffrey Chamberlain, PhD
Tami John, MD
Tami John, MD
Tami John, MD
Matthew Ku, MBBS, FRACP, RACP, FRCPA/RCPA, PhD, an associate professor and the lymphoma stream lead at St Vincent’s Hospital
Saurabh Dahiya, MD, FACP, an associate professor of medicine at Stanford University School of Medicine; as well as clinical director of Cancer Cell Therapy in the Division of Blood and Marrow Transplantation and Cell Therapy at Stanford Medicine
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Related Content
© 2025 MJH Life Sciences

All rights reserved.