Dr. Ruan on Future Research With CAR T-Cell Therapy in MCL

Video

Jia Ruan, MD, PhD, discusses future research with CAR T-cell therapy in mantle cell lymphoma.

Jia Ruan, MD, PhD, associate professor of clinical medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, discusses future research with CAR T-cell therapy in mantle cell lymphoma (MCL).

In July 2020, the FDA approved the CAR T-cell therapy brexucabtagene autoleucel (Tecartus) as a treatment for patients with relapsed/refractory MCL. The approval was based on findings from the phase 2 ZUMA-2 trial in which the CAR T-cell product elicited an 87% objective response rate and a 62% complete response rate in this patient population. Despite the impressive efficacy rate, toxicity remains a concern with CAR T-cell therapy, says Ruan.

Future research efforts with CAR T-cell therapy are looking to bring the modality into earlier lines of therapy, says Ruan. Additionally, combining the therapy with other agents may augment the effectiveness of brexucabtagene autoleucel while minimizing potential toxicities, Ruan explains.

Additional research is also needed to determine which patients are best suited to receive CAR T-cell therapy. Currently, younger, fit patients are eligible; however, finding ways to bring CAR T-cell therapy to older patients with comorbidities is critical because this patient population comprises a large proportion of patients with MCL, concludes Ruan.

Newsletter

Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.

Recent Videos
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira, and Kilian Guse, PhD, the vice president of genetic medicine platforms at Pacira
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira
Jeffrey Chamberlain, PhD
Tami John, MD
Tami John, MD
Tami John, MD
Matthew Ku, MBBS, FRACP, RACP, FRCPA/RCPA, PhD, an associate professor and the lymphoma stream lead at St Vincent’s Hospital
Saurabh Dahiya, MD, FACP, an associate professor of medicine at Stanford University School of Medicine; as well as clinical director of Cancer Cell Therapy in the Division of Blood and Marrow Transplantation and Cell Therapy at Stanford Medicine
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Related Content
© 2025 MJH Life Sciences

All rights reserved.