Dr. Wang on the Safety Profile of Brexucabtagene Autoleucel in Relapsed/Refractory MCL
Michael Wang, MD, discusses the safety profile of the CAR T-cell therapy brexucabtagene autoleucel in relapsed/refractory mantle cell lymphoma.
Michael Wang, MD, a professor in the Department of Lymphoma and Myeloma at The University of Texas MD Anderson Cancer Center, discusses the safety profile of the CAR T-cell therapy brexucabtagene autoleucel (Tecartus; formerly KTE-X19) in relapsed/refractory mantle cell lymphoma (MCL).
On July 24, 2020, the
Regarding safety, the rates of cytokine release syndrome (CRS) and neurotoxicity were favorable, says Wang. CRS onset typically occured within 1 or 2 days after infusion and peaked around 1 week, while neurotoxicity peaked between days 10 and 14.
Both CRS and neurotoxicity were well managed with tocilizumab (Actemra) or corticosteroids, Wang explains. Though, 1 patient died as a result of CRS.
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