Frank Borriello, MD, PhD, on Promising Activity of SUPLEXA-101 Across Cancers

Video

The scientific cofounder and chief executive officer of Alloplex Biotherapeutics discussed early data from a phase 1 trial of the PBMC-derived therapy.

“So far, the results have been very interesting... I'm very happy to report that we have 0 drug-related adverse events...the second thing that we noticed is that many of the patients that are in our trial [with] 12 cancers represented in the first 25 patients... at the first measurement, after starting to receive our therapy, the tumors stabilize. They don’t continue to grow. And this is just after 3 doses of our weekly therapy."

SUPLEXA-101, a peripheral blood mononuclear cell (PBMC)-derived activated white blood cell therapy comprised predominantly of natural killer (NK) cells, natural killer T (NKT) cells, γδ T cells, and cytotoxic CD8-positive and CD4-positive T lymphocytes αβ T cells, has demonstrated an excellent safety profile and promising clinical activity across solid and liquid tumor types.

Data from the phase 1 trial (NCT05237206) evaluating SUPLEXA-101 were presented at the World Oncology Cell Therapy Congress (WOCTC) held April 25-26 in Boston, Massachusetts, by Frank Borriello, MD, PhD, scientific cofounder and chief executive officer, Alloplex Biotherapeutics. CGTLive spoke with Borriello to learn more about SUPLEXA-101 and the potential advantages that it may offer across different cancers.

Borriello discussed the manufacturing, cost, and accessibility advantages that the cell therapy offers due to it being a target-agnostic therapy. He also discussed the pharmacodynamics observed in the first treated patients, including white blood cell profiles in these patients being corrected toward normal levels within 2 weeks of administration and a marked decrease in myeloid-derived suppressor cells which are correlated with patient responses. He also hypothesized that using SUPLEXA-101 in combination with other treatment strategies, such as checkpoint inhibitors, may yield more durable and efficacious responses in treating cancers.

REFERENCE
Borriello, F. Preliminary First-in-Human Data from an Exploratory Clinical Trial of SUPLEXA Therapeutic Cells. Presented at: WOCTC; April 25-26; Boston, Massachusetts.
Recent Videos
Lucas Harrington, PhD, the cofounder and chief scientific officer of Mammoth Biosciences
Stephanie Tagliatela on Researching AAV for Lennox-Gastaut, Alzheimer Disease, SCN9a Pain
Miloš Miljković, MD, on mRNA-CAR-T Descartes-08's Potential for Treating Myasthenia Gravis
Manali Kamdar, MD, on Liso-Cel's Ongoing Benefit in the Treatment Lanscape for LBCL
Steve Kanner, PhD, the chief scientific officer of Caribou Biosciences
David Dimmock, MBBS, on AI-Guided ASO Development for Ultra-Rare Diseases
Manali Kamdar, MD, on The Importance of Bringing Liso-Cel to Earlier Lines of Lymphoma Treatment
Subhash Tripathi, PhD, on Generating In Vivo CARs With A2-CAR-CISC EngTreg Cells
Luke Roberts, MBBS, PhD, on Challenges in Developing Gene Therapy for Heart Failure
Steve Kanner, PhD, the chief scientific officer of Caribou Biosciences
© 2024 MJH Life Sciences

All rights reserved.