Novel Treatments for Multiple Myeloma: C. Ola Landgren, MD, PhD


The inaugural leader of the Experimental Therapeutics Program at Sylvester Comprehensive Cancer Center, University of Miami discussed exciting novel therapeutic approaches in multiple myeloma.

This content originally appeared on our sister site, OncLive.

OncLive spoke with C. Ola Landgren, MD, PhD, inaugural leader, Experimental Therapeutics Program, Sylvester Comprehensive Cancer Center, University of Miami, about novel therapeutic approaches that are generating excitement in multiple myeloma.

Landgren discussed results from the phase 1b/2 CARTITUDE-1 trial (NCT03548207) that showed that the CAR T-cell therapy ciltacabtagene autoleucel (cilta-cel) demonstrated sustained efficacy and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma. For the first time, there is a CAR T-cell therapy for this patient population that is able to induce a median progression-free survival of close to 2 years, according to Landgren. Although the median follow-up time is limited and the sample size is not very large, these data are exciting, Landgren says.

However, other novel therapeutic approaches are also emerging in the treatment paradigm and they may challenge CAR T-cell therapies, Landgren notes. For example, unlike cell therapies, bispecific antibodies do not need to be administered in a hospital, Landgren notes. However, CAR T-cell therapies and natural killer cell therapies may still appeal to patients because they can be given via a single infusion. Overall, there is an opportunity for both cell and antibody therapies for patients with this disease, Landgren concludes.

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