Shahzad Raza, MD, on Future Plans for CAR T-Cell Therapy NXC-201 in R/R Light Chain Amyloidosis

Immix Biopharma and its subsidiary Nexcella are currently developing NXC-201, an investigational autologous BCMA-directed chimeric antigen receptor T-cell (CAR-T) therapy, for the treatment of relapsed/refractory (r/r) light chain (AL) amyloidosis. Notably, early data from the phase 1b/2 NEXICART-2 clinical trial (NCT06097832) evaluating the therapy in the United States were recently presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, held May 30 to June 3, in Chicago, Illinois.

At the conference CGTLive®’s sister site, OncLive®, spoke with Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic who coauthored the study presented at ASCO, about the key results and their implications. Afterwards, Raza was asked about future plans for evaluating the CAR-T product in AL amyloidosis and unanswered questions and challenges that still need to be addressed. Raza emphasized that while patients with advanced cardiac amyloidosis (stage 3b) were excluded from the current trial, future studies should explore its use in this high-risk group if safety and efficacy continue to hold. Raza stressed the urgent need for effective second-line treatments and suggested offering CAR-T therapy earlier in the disease course. He highlighted the potential for “treatment holidays,” where patients could avoid continuous therapies after receiving CAR-T, which could improve quality of life.

Raza also spoke about challenges in patient eligibility for treatment, emphasizing the importance of being free from active infections and other disease. He then mentioned his excitement about another presentation at ASCO, which focused on the use of teclistamab, a Bispecific T-cell engager (BiTE), for AL amyloidosis. He spoke about how teclistamab and CAR-T may allow for patients to have multiple treatment options for r/r AL amyloidosis in the future.