Assessing Axi-Cel in R/R LBC Lymphoma in ZUMA-7: Frederick Locke, MD

Video

The vice chair, Blood and Marrow Transplant and Cellular Immunotherapy Program, and co-leader, Immuno-Oncology, Moffitt Cancer Center, discussed the results of the phase 3 ZUMA-7 trial.

This content originally appeared on our sister site, OncLive.

OncLive spoke with Frederick Locke, MD, vice chair, Department of Blood and Marrow Transplant and Cellular Immunotherapy Program, and co-leader, Immuno-Oncology, Moffitt Cancer Center, to learn more about the results of the phase 3 ZUMA-7 trial (NCT03391466) in patients with large B-cell lymphoma ​(LBCL).

Data from the ZUMA-7 trial were presented at the 2021 ASH Annual Meeting & Exposition. The trial's primary endpoint is event-free survival (EFS), defined as time from randomization to the earliest date of disease progression including death due to any cause or commencement of different anti-lymphoma therapy.

Data demonstrated that over 90% of patients randomized received CAR T-cell therapy with axicabtagene ciloleucel (axi-cel; Yescarta), whereas about 30% of patients received a definitive autologous hematopoietic stem cell transplant, Locke explained.

The findings from the study demonstrated a median EFS of 8.3 months with axi-cel vs 2 months with standard of care in patients with relapsed/refractory LBCL, Locke continues. Notably, the 24-month EFS rate was 40.5% compared with 16.3%, respectively. This means that at 2 years after randomization, over 40% of patients who received axi-cel arm did not require additional therapy and remained in remission, Locke concludes.

For more coverage of ASH 2021, click here.

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