Bijal Shah, MD, on AUTO1 in R/R B-Cell ALL and the FELIX Trial

Video

Shah explained that the trial is unique due to its inclusion of patients with MRD–positive B-ALL.

This content originally appeared on our sister site, OncLive.

AUTO1 (CAT19-41BB-Z CAR T-cells) is an autologous low-affinity CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy being evaluated in the phase 1/2 FELIX trial (NCT04404660) for the treatment of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). The trial is unique due to its inclusion of patients with minimal residual disease (MRD)–positive B-ALL in 1 of its cohorts.

In an interview with OncLive, Bijal Shah, MD, MS, associate member, Department of Malignant Hematology, Moffitt Cancer Center, discussed the trial's importance. He explained that the inclusion of these patients is based on multiple retrospective observations indicating that patients with low disease burden have the best outcomes in terms of toxicity, response, and duration of response. Shah also clarified that "low disease burden" ideally referes to undectable disease in this context.

Recent Videos
Mark Hamilton, MD, PhD, a hematology-oncology and bone marrow transplant (BMT) cell therapy fellow at Stanford University
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Sarah Larson, MD, the medical director of the Immune Effector Cell Therapy Program in the Division of Hematology/Oncology at David Geffen School of Medicine at University of California, Los Angeles (UCLA)
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
Georg Schett, MD, vice president research and chair of internal medicine at the University of Erlangen – Nuremberg
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Related Content
© 2025 MJH Life Sciences

All rights reserved.