Clinical Implications of Tisagenlecleucel in B-ALL Treatment: Michael R. Grunwald, MD, FACP

Video

The hematologic oncologist at the Levine Cancer Institute discussed the clinical implications of tisagenlecleucel in the treatment of patients with B-cell acute lymphoblastic leukemia.

This content originally appeared on our sister site, OncLive.

OncLive spoke with Michael R. Grunwald, MD, FACP, clinical assistant professor of medicine, University of North Carolina, and hematologist/ oncologist, Levine Cancer Institute, Atrium Health, about the potential of tisagenlecleucel (Kymriah) in the treatment of patients with B-cell acute lymphoblastic leukemia (B-ALL).

Having a CAR T-cell therapy available for the treatment of patients with B-ALL has being exciting, Grunwald says. However, the agent is currently only FDA approved for use in patients up to age 25 years whose disease is refractory or in second or later relapse, Grunwald notes.

Further studies of tisagenlecleucel, as well as similar agents, will be important for older patients with B-ALL because more options are needed in this population, Grunwald continues. For younger patients, however, having this agent available has been significant, as it can get them back into remission. Sometimes patients who receive the agent can experience a very durable remission following relapse, Grunwald concludes.

Newsletter

Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.

Recent Videos
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira, and Kilian Guse, PhD, the vice president of genetic medicine platforms at Pacira
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira
Jeffrey Chamberlain, PhD
Tami John, MD
Tami John, MD
Tami John, MD
Matthew Ku, MBBS, FRACP, RACP, FRCPA/RCPA, PhD, an associate professor and the lymphoma stream lead at St Vincent’s Hospital
Saurabh Dahiya, MD, FACP, an associate professor of medicine at Stanford University School of Medicine; as well as clinical director of Cancer Cell Therapy in the Division of Blood and Marrow Transplantation and Cell Therapy at Stanford Medicine
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Related Content
© 2025 MJH Life Sciences

All rights reserved.