Dr. Andreadis on CAR T-Cell Therapy in Relapsed/Refractory MCL

Video

Charalambos (Babis) Andreadis, MD, MSCE, discusses the emergence of CAR T-cell therapy in relapsed/refractory mantle cell lymphoma.

Charalambos (Babis) Andreadis, MD, MSCE, associate professor of clinical medicine, Department of Medicine, University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, discusses the emergence of CAR T-cell therapy in relapsed/refractory mantle cell lymphoma (MCL).

The BTK inhibitors ibrutinib (Imbruvica), acalabrutinib (Calquence), and zanubrutinib (Brukinsa) are active in relapsed/refractory MCL and have shown significant response rates; however, patients continue to relapse on these regimens, explains Andreadis. The median duration of response for BTK inhibitors is 1.5 years. Therefore, new therapies are necessary for this patient population, says Andreadis.

The emergence of CAR T-cell therapy has shown significant benefit in patients with relapsed/refractory MCL who are heavily pretreated. The CAR T-cell therapies lisocabtagene maraleucel (JCAR017) and axicabtagene ciloleucel (Yescarta), according to Andreadis, are showing 70% to 90% response rates and 50% to 60% complete response rates in patients with relapsed/refractory disease. Andreadis believes CAR T-cell therapy will be significant in the future of MCL treatment.

Recent Videos
Haydar Frangoul, MD, the medical director of pediatric hematology/oncology at Sarah Cannon Research Institute and Pediatric Transplant and Cellular Therapy Program at TriStar Centennial
David Barrett, JD, the chief executive officer of ASGCT
Georg Schett, MD, vice president research and chair of internal medicine at the University of Erlangen – Nuremberg
David Barrett, JD, the chief executive officer of ASGCT
Bhagirathbhai R. Dholaria, MD, an associate professor of medicine in malignant hematology & stem cell transplantation at Vanderbilt University Medical Center
Caroline Diorio, MD, FRCPC, FAAP, an attending physician at the Cancer Center at Children's Hospital of Philadelphia
R. Nolan Townsend; Sandi See Tai, MD; Kim G. Johnson, MD
Daniela van Eickels, MD, PhD, MPH, the vice president and head of medical affairs for Bristol Myers Squibb’s Cell Therapy Organization
Paul Melmeyer, MPP, the executive vice president of public policy & advocacy at MDA
© 2024 MJH Life Sciences

All rights reserved.