Dr. Cavo on Upfront ASCT in Multiple Myeloma
Michele Cavo, MD, professor, Seràgnoli Institute of Hematology Bologna University School of Medicine, discusses the results of the phase III EMN02/HO95 MM trial, which compared the efficacy of upfront autologous stem cell transplantation versus novel agent-based therapy for the treatment of patients with multiple myeloma.
Michele Cavo, MD, professor, Seràgnoli Institute of Hematology Bologna University School of Medicine, discusses the results of the phase III EMN02/HO95 MM trial, which compared the efficacy of upfront autologous stem cell transplantation (ASCT) versus novel agent-based therapy for the treatment of patients with multiple myeloma.
In the study, patients were randomized to receive 4 cycles of bortezomib, melphalan, and prednisone versus high-dose melphalan and single or double ASCT as intensification therapy following induction with bortezomib, cyclophosphamide, and dexamethasone and subsequent collection of peripheral blood stem cells.
The difference between the 2 arms was statistically significant, Cavo explains. Additionally, there was an improvement in progression-free survival with ASCT. Results show that ASCT remains to be a preferred treatment regimen in newly diagnosed patients with multiple myeloma, he adds.
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