Dr. Deol on the Nuances of Utilizing CAR T-Cell Therapy in Lymphoma and Leukemia


Abhinav Deol, MD, discusses the nuances of utilizing CAR T-cell therapy in lymphoma and leukemia.

Abhinav Deol, MD, associate clinical professor, Barbara Ann Karmanos Cancer Institute, discusses the nuances of utilizing CAR T-cell therapy in lymphoma and leukemia.

CAR T-cell therapy is an important modality of treatment ​for patients with lymphoma and leukemia. 

​However, patients must demonstrate good performance status​, along with ​good social support ​to be eligible for treatment, says Deol. As such, CAR T-cell therapy may not be an option for every patient. 

Additionally, after ​patients receive an infusion ​of CAR T-cell therapy, they must be observed for potential neurological toxicity​, hypogammaglobulinemia​, and other long-term adverse effects that could require chronic immunoglobulin replacement​, Deol says. Moreover, patients may develop cytopenias that can last ​for up to 1 year ​following infusion. 

The field of lymphoma and leukemia continues to gain experience in administering this therapeutic modality and, in the near future, additional ​regulatory approvals for the modality are expected, Deol concludes. 

Related Videos
Sowmya Viswanathan, PhD, on Translating Cell Therapies to the Clinic at ISCT 2024
Omar Nadeem, MD, on Initial Efficacy of GPRC5D-CAR in R/R Multiple Myeloma
Omer A. Abdul Hamid, MD, on Improving Gene Therapy’s Effect and Accessibility
George Tachas, PhD, on Tackling DMD Treatment From Multiple Angles
David Suhy, PhD, the cofounder and chief scientific officer of Earli
Deepak L. Bhatt, MD, MPH, MBA, on Incorporating AI into Genetic Research for Cardiovascular Disease
Jeffrey Chamberlain, PhD, on Helping Progress Cell and Gene Therapy Development
Jonathan W. Weinsaft, MD, on Integrating Genetic Research into Cardiovascular Medicine
Jacques Galipeau, MD, on Highlights from ISCT 2024’s Presidential Plenary
Vanee Pho, PhD, the senior director of product management, cell and gene therapy, at Mission Bio
© 2024 MJH Life Sciences

All rights reserved.