Dr. Goy on CAR-Modified T Cells in Lymphoma

Video

Andre Goy, MD, MS, from the John Theurer Cancer Center, discusses the apparent effectiveness of CD19-targeted CAR-modified T cells as a treatment for patients with various types of lymphoma.

Andre Goy, MD, MS, the Chief of the Division of Lymphoma at the John Theurer Cancer Center, discusses the apparent effectiveness of CD19-targeted chimeric antigen receptor (CAR)-modified T cells as a treatment for patients with various types of lymphoma.

Several versions of CAR-modified T cells exist, each with different side effects and constructs. However, when the evidence on each is taken together, the proof of principle is quite amazing, Goy believes.

The treatments can be utilized in a variety of settings. In some cases, the T cells are modified in the relapsed setting, following an allogeneic transplant. Additionally, autologous T cells can be utilized in the case of aggressive lymphomas, where there is only a small chance for relapse. In some studies, these treatments were used as a consolidative therapy, post-transplant, Goy states.

Ultimately, this will be a very important tool in lymphoma, Goy believes. These engineered T cell therapies are the ideal vaccines, since they are a cell therapy that persists to fights against recurrence, Goy believes. In general, these agents work by depleting CD19-positive B cells, which make antibodies. As a result of this mechanism, most patients will require lifetime intravenous immunoglobulin.

As research moves forward, Goy hopes the technology will evolve to provide further control for the lifespan of the T cells. These treatments hold the potential to completely change the treatment landscape in lymphoma, Goy states.

<<<

View more from the 2013 ASH Annual Meeting

Related Videos
Mitchel Horwitz, MD
Bruce Cree, MD, PhD, MAS, a professor of neurology and the clinical research director of the University of California San Francisco (UCSF) Multiple Sclerosis Center
Emilie Aschenbrenner, PharmD, BCOP, a hematology coordinator for pharmacy at Froedtert and the Medical College of Wisconsin
Raj Chovatiya, MD, PhD
Jessica S. Little, MD, a transplant infectious diseases physician at Dana-Farber Cancer Institute
Nirav N. Shah, MD
Alexis Kuhn, PharmD, BCOP, a pediatric oncology pharmacist at the Mayo Clinic
Haydar Frangoul, MD
Aimee C. Talleur, MD, a physician at St. Jude Children’s Research Hospital
Related Content
© 2024 MJH Life Sciences

All rights reserved.