Dr. Maziarz on Unanswered Questions With CAR T-Cell Therapy in DLBCL

Richard T. Maziarz, MD, professor of medicine at Oregon Health & Science University, Knight Cancer Institute, discusses unanswered questions with CAR T-cell therapy in diffuse large B-cell lymphoma.

Richard T. Maziarz, MD, professor of medicine at Oregon Health & Science University, Knight Cancer Institute, discusses unanswered questions with CAR T-cell therapy in diffuse large B-cell lymphoma (DLBCL).

Traditionally in DLBCL, physicians expected 15% to 20% of patients to be alive at the 2-year mark. Now, with the emergence of CAR T-cell therapy, researchers expect approximately 40% of patients to be alive at the 2-year mark. This is encouraging because a survival of at least 2 years indicates long-term survival, Maziarz says. However, that still leaves 60% of patients who need effective therapy. Therefore, a better understanding of what drives resistance is crucial.

Moreover, CAR T-cell therapy is associated with unique toxicities, and researchers need to make the treatment safer so more patients can receive it. For example, a proliferation event can occur as a result of cells growing fast.

Related Videos
Binod Dhakal, MD, on Assessing Cilta-Cel in Lenalidomide-Refractory Multiple Myeloma
Brian Van Tine, MD, PhD, on Further Research With Cell Therapy in Synovial Sarcoma
Brian Van Tine, MD, PhD, on Continued Durability of Afami-Cel in Synovial Sarcoma
Thomas McCauley, PhD, on Treating Solid Tumors With Epigenomic Controllers
Rebecca Cottman, PhD, on Creating Regulated Gene Circuits to Enhance Cell Therapy Cytotoxicity
John Leonard, PhD, on an AAV Approach to Exon 51 Skipping in DMD
© 2023 MJH Life Sciences

All rights reserved.