Dr. McDermott on an Analysis of the CheckMate-214 Study in RCC

Video

David F. McDermott, MD, director of the Biologic Therapy Program at Beth Israel Deaconess Medical Center, discusses an analysis of the CheckMate-214 study in advanced renal cell carcinoma (RCC).

David F. McDermott, MD, director of the Biologic Therapy Program at Beth Israel Deaconess Medical Center, discusses an analysis of the CheckMate-214 study in advanced renal cell carcinoma (RCC).

Findings from the CheckMate-214 trial showed that frontline treatment with the combination of nivolumab (Opdivo) and ipilimumab (Yervoy) reduced the risk of death by 32% compared with sunitinib (Sutent) for patients with metastatic RCC. The trial led to the FDA approval of the combination as a frontline treatment for intermediate- and poor-risk patients with advanced RCC.

In an analysis presented at the 2018 ESMO Congress, investigators evaluated the treatment-free interval (TFI) following discontinuation of first-line nivolumab plus ipilimumab or sunitinib in patients with advanced RCC on the CheckMate-214 trial. Findings from this analysis showed that in patients with intermediate- or poor-risk disease, nivolumab plus ipilimumab was associated with a significantly longer TFI. Investigators noted that TFI should be considered as a part of the traditional efficacy measures when evaluating therapeutic options for patients with advanced RCC.

Newsletter

Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.

Recent Videos
Annaiz Grimm, BS, a research scientist at Seattle Children's Research Institute
Prerna Mewawalla, MD, medical director of Apheresis and a hematologist-oncologist in the Division of Hematology and Cellular Therapy at Allegheny Health Network, as well as an associate professor at the Drexel University College of Medicine
Surbhi Sidana, MD, an assistant professor of medicine, bone marrow transplantation, and cellular therapy at Stanford
© 2025 MJH Life Sciences

All rights reserved.