Dr. Meric-Bernstam Discusses Novel Combination in RCC

Video

Funda Meric-Bernstam, MD, chair, Department of Investigational Cancer Therapeutics, medical director, Institute for Personalized Cancer Therapy, professor of medicine, The University of Texas MD Anderson Cancer Center, discussed preliminary data with a novel combination in the treatment of patients with renal cell carcinoma.

Funda Meric-Bernstam, MD, chair, Department of Investigational Cancer Therapeutics, medical director, Institute for Personalized Cancer Therapy, professor of medicine, The University of Texas MD Anderson Cancer Center, discusses preliminary data with a novel combination in renal cell carcinoma (RCC).

In a phase I study presented at the 2019 Genitourinary Cancers Symposium, the glutaminase inhibitor CB-839 was combined with the VEGF TKI cabozantinib (Cabometyx). Meric-Bernstam says that preliminary efficacy looks promising and that the combination had a similar toxicity profile to cabozantinib alone.

Of the 13 patients enrolled in the study, 12 were evaluable for response. Objective response rate (ORR) in the general population of patients with RCC was 42%. Of the 10 patients with clear-cell RCC, the ORR was 50%. Moreover, the combination led to durable responses in a heavily pretreated patient population, Meric-Bernstam adds. Five patients remained on therapy for 14 months or longer, and 3 patients remained on treatment at the time of data cut-off. Notably, some patients demonstrated delayed response, so longer-term follow-up will paint a clearer picture of the durability of these responses, says Meric-Bernstam.

Related Videos
Daniel Hart, PhD, on CRISPR-Mediated, In Vivo Epigenomic Activation
Luke Roberts, MBBS, PhD, on Developing Gene Therapy for Congestive Heart Failure
PJ Brooks, PhD, on Improved Newborn Screening, Non-Viral Gene Editing: New Frontiers for Neuromuscular Disease
Sowmya Viswanathan, PhD, on Translating Cell Therapies to the Clinic at ISCT 2024
Omar Nadeem, MD, on Initial Efficacy of GPRC5D-CAR in R/R Multiple Myeloma
Omer A. Abdul Hamid, MD, on Improving Gene Therapy’s Effect and Accessibility
George Tachas, PhD, on Tackling DMD Treatment From Multiple Angles
David Suhy, PhD, the cofounder and chief scientific officer of Earli
Deepak L. Bhatt, MD, MPH, MBA, on Incorporating AI into Genetic Research for Cardiovascular Disease
Jeffrey Chamberlain, PhD, on Helping Progress Cell and Gene Therapy Development
© 2024 MJH Life Sciences

All rights reserved.