Dr. Mudad on RELAY Trial for EGFR-Mutant NSCLC

Video

Raja Mudad, MD, FACP, discusses the RELAY trial and using doublet therapy to treat EGFR-mutant non–small cell lung cancer.

Raja Mudad, MD, FACP, a founding partner at Florida Precision Oncology, discusses the RELAY trial and using doublet therapy to treat EGFR-mutant non—small cell lung cancer (NSCLC).

The RELAY trial examined adding ramucirumab (Cyramza) to erlotinib (Tarceva) to see if the agents work better as a combination in patients with NSCLC who have an EGFR mutation. The progression-free survival (PFS) between single-agent erlotinib plus ramucirumab versus erlotinib plus placebo was 19.4 months versus 12.4 months, respectively, explains Mudad. Additionally, there was a significant elongation of PFS in single-agent erlotinib that is not as long as what would be seen with single-agent osimertinib (Tagrisso), according to Mudad.

Toxicity for the combination regimen had more toxicity related to VEGF inhibition, such as bleeding or thrombosis. Mudad believes the job of the physician is to find the ideal way of combining and sequencing [agents] to do better than single agents. One possibility is to start with a second- or first-generation EGFR inhibitor plus a VEGF inhibitor and follow that up with a third-generation EGFR inhibitor, says Mudad. Current trials are looking at osimertinib (Tagrisso) combined with ramucirumab or bevacizumab (Avastin), concludes Mudad.

Recent Videos
Peter Cook, PhD, a senior research scientist at Seattle Children’s Research Institute
Nicholas Giovannone, PhD, a senior principal scientist at Regeneron
Brian Kim, MBA, the chief executive officer of Mission Bio
Kiran Musunuru, MD, PhD, a physician-scientist and Barry J. Gertz Professor for translational research in the Perelman School of Medicine at the University of Pennsylvania and CHOP and Rebecca Ahrens-Nicklas, MD, PhD, a physician-scientist and director of the Gene Therapy for Inherited Metabolic Disorders Frontier Program at CHOP
Ben Samelson-Jones, MD, PhD, an assistant professor of pediatric hematology at Perelman School of Medicine, University of Pennsylvania, and the associate director of clinical in vivo gene therapy at Children’s Hospital of Philadelphia
Kiran Musunuru, MD, PhD, a physician-scientist and Barry J. Gertz Professor for translational research in the Perelman School of Medicine at the University of Pennsylvania and CHOP and Rebecca Ahrens-Nicklas, MD, PhD, a physician-scientist and director of the Gene Therapy for Inherited Metabolic Disorders Frontier Program at CHOP
Roger Hajjar, MD, the director of the GCTI
Kiran Musunuru, MD, PhD, a physician-scientist and Barry J. Gertz Professor for translational research in the Perelman School of Medicine at the University of Pennsylvania and CHOP and Rebecca Ahrens-Nicklas, MD, PhD, a physician-scientist and director of the Gene Therapy for Inherited Metabolic Disorders Frontier Program at CHOP
Nicholas Giovannone, PhD, a senior principal scientist at Regeneron
Nathan Yozwiak, PhD, on Collaboration for Cell and Gene Therapy Development
© 2025 MJH Life Sciences

All rights reserved.