Dr. Perales on CAR T-Cell Therapy in DLBCL and Follicular Lymphoma

Video

Miguel-Angel Perales, MD, discusses the use of CAR T-cell therapy in diffuse large B-cell lymphoma and transformed follicular lymphoma.

Miguel-Angel Perales, MD, deputy chief, Adult Bone Marrow Transplant Service, director, Adult Bone Marrow Transplantation Fellowship Program, Memorial Sloan Kettering Cancer Center, discusses the use of CAR T-cell therapy in diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma.

There are currently 2 approved CAR T-cell products: tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (axi-cel; Yescarta), explains Perales. These products are primarily approved for patients with DLBCL in third-line therapy.

Now that the drugs have been approved for a short period of time, real-world data are starting to emerge and is showing similar results to what was seen in clinical trials, says Perales. However, according to Perales, about 43% of the patients being treated with CAR T-cell therapy in the real-world setting would not have qualified for the clinical trials. The indication for DLBCL or transformed follicular lymphoma is still followed, but some of the other parameters around patient eligibility, including comorbidity factors, are being ignored. Therefore, patients with low platelets and active deep vein thrombosis are now allowed to be treated with CAR T-cell therapy, states Perales.

The side-by-side comparison of the ZUMA-1 trial results with real-world experience shows similar safety and efficacy results. However, one limitation was the short follow-up at less than 4 months, which will hopefully be updated soon, concludes Perales.

Newsletter

Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.

Recent Videos
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira, and Kilian Guse, PhD, the vice president of genetic medicine platforms at Pacira
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira
Jeffrey Chamberlain, PhD
Tami John, MD
Tami John, MD
Tami John, MD
Matthew Ku, MBBS, FRACP, RACP, FRCPA/RCPA, PhD, an associate professor and the lymphoma stream lead at St Vincent’s Hospital
Saurabh Dahiya, MD, FACP, an associate professor of medicine at Stanford University School of Medicine; as well as clinical director of Cancer Cell Therapy in the Division of Blood and Marrow Transplantation and Cell Therapy at Stanford Medicine
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Related Content
© 2025 MJH Life Sciences

All rights reserved.