Dr. Siddiqi on the Rationale to Evaluate CAR T-Cell Therapy in CLL

Video

Tanya Siddiqi, MD, discusses the rationale to evaluate CAR T-cell therapy in chronic lymphocytic leukemia.

Tanya Siddiqi, MD, an assistant clinical professor in the Department of Hematology and Hematopoietic Cell Transplantation at the City of Hope, discusses the rationale to evaluate CAR T-cell therapy in chronic lymphocytic leukemia (CLL).

In diseases such as acute lymphoblastic leukemia, aggressive B-cell non-Hodgkin lymphomas such as diffuse large B-cell lymphoma, and mantle cell lymphoma, CD19-directed CAR T-cell therapy was introduced with the hope of addressing an immediate unmet clinical need, explains Siddiqi. As such, the utility of this modality in CLL went largely unknown as the need for the therapy in other disease types was greater than in this disease.

However, with the growth of CAR T-cell therapy, the field of CLL is beginning to explore the modality for use in patients who have progressed on novel oral agents, such as ibrutinib (Imbruvica) or venetoclax (Venclexta), says Siddiqi. Currently, the field has limited salvage options for these patients, concludes Siddiqi.

Recent Videos
Daniela van Eickels, MD, PhD, MPH, the vice president and head of medical affairs for Bristol Myers Squibb’s Cell Therapy Organization
Paul Melmeyer, MPP, the executive vice president of public policy & advocacy at MDA
Daniela van Eickels, MD, PhD, MPH, the vice president and head of medical affairs for Bristol Myers Squibb’s Cell Therapy Organization
Arun Upadhyay, PhD, the chief scientific officer and head of research, development, and Medical at Ocugen
Arun Upadhyay, PhD, the chief scientific officer and head of research, development, and Medical at Ocugen
John Brandsema, MD, a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia
John Brandsema, MD, a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia
Barry J. Byrne, MD, PhD, the chief medical advisor of Muscular Dystrophy Association (MDA) and a physician-scientist at the University of Florida
John Brandsema, MD, a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia
© 2024 MJH Life Sciences

All rights reserved.