Episode Breakdown
- 0:00 – Intro and guest introduction
- 2:00 – Challenges in predicting toxicities in preclinical models
- 10:00 – How manufacturing parameter changes can affect toxicity rates
- 13:06 – Strategies for managing inflammatory toxicities in smaller medical centers
- 19:52 – Goal of decoupling treatment potency from toxicity
- 20:44 – Potential for future unknown toxicities in immunotherapies
- 24:52 – Challenges in defining and identifying immune effector cell-associated HLH-like syndrome (IEC-HS) biomarkers
We're excited to introduce another episode of the ImmunoLogic video podcast, hosted by Joseph Fraietta, PhD, an assistant professor of microbiology and the director of the Fraietta Lab at the University of Pennsylvania! Fraietta is joined by cohost Janna Minehart, MD, a clinical fellow in oncology (MSTR Program) at the University of Pennsylvania. Our hope is that this show will serve as a critical forum for clinicians, translational researchers, and biotech professionals to explore the evolving landscape of immunotherapy. We're seeking to bridge cutting-edge research with practical applications and delve into how immune-based therapies transition from innovative discoveries to transformative patient care solutions
In this episode, the cohosts speak with Caroline Diorio, MD, FRCPC, FAAP, an attending physician at the Cancer Center at Children's Hospital of Philadelphia, about her research into inflammatory toxicities in cell therapy. Diorio, Fraietta, and Minehart covered topics including predicting and managing toxicities like cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), the need for rigorous research to understand the underlying biology of these toxicities, the importance of transparency in manufacturing processes, and the potential for decoupling potency from toxicity.
ImmunoLogic is tailored for an audience fluent in the language of medicine and biotechnology, offering data-driven insights while maintaining accessibility. This podcast is an essential resource for those driving the future of immunotherapy.
Interested in co-hosting an episode or being a guest? Have feedback to share? If you'd like to get in touch to talk about the show, contact our editorial director, Matt Hoffman: [email protected].
