Mitigating Adverse Events in CAR T-Cell Therapy: Mounzer Agha, MD
The director of the Mario Lemieux Center for Blood Cancers at UPMC Hillman Cancer Center discussed strategies to manage AEs associated with CAR T therapy.
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Cancer Network spoke with Mounzer Agha, MD, of the University of Pittsburgh School of Medicine Hillman Cancer Center, about the encouraging safety profile reported from the
The strategies he detailed included reducing neurologic adverse events by use of more effective bridging therapy, frequent assessment of CAR T-cell–related immune effector cell-associated neurotoxicity syndrome, and handwriting assignments to detectmicrographia, among others.2
Transcription:
The most important thing I’d really like to emphasize is that in CARTITUDE-2, we showed an excellent safety profile.1 So, unlike with
REFERENCES
1. Agha ME, Cohen AD, Madduri D, et al. CARTITUDE-2: Efficacy and safety of ciltacabtagene autoleucel (cilta-cel), a BCMA-directed CAR T-cell therapy, in patients with progressive multiple myeloma (MM) after one to three prior lines of therapy. J Clin Oncol. 2021;39(suppl 15):8013. doi:10.1200/JCO.2021.39.15_suppl.8013
2. Einsele H, Parekh SS, Madduri D, et al. Incidence, mitigation, and management of neurologic adverse events in patients with multiple myeloma (MM) treated with ciltacabtagene autoleucel (cilta-cel) in CARTITUDE-2. J Clin Oncol. 2021;39(suppl 15):8028. doi:10.1200/JCO.2021.39.15_suppl.8028
3. Usmani SZ, Berdeja JG, Madduri D, et al. Ciltacabtagene autoleucel, a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed/refractory multiple myeloma (R/R MM): Updated results from CARTITUDE-1. J Clin Oncol. 2021,39(suppl 15; abstr 8005). doi:10.1200/JCO.2021.39.15_suppl.8005
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