Opportunities for CAR T-Cell Therapy in Solid Tumors

Video

Radek Špíšek, PhD, co-founder and chief executive officer of SOTIO Global, and Geoffrey Hodge, chief executive officer of SOTIO BioTech US, join CGTL to discuss its 3 technology platforms and how they are leveraging them to attack the solid tumor micro-environment.

"What is it about the solid tumor micro-environment that makes it challenging for T cells? One of the things is that it really is a tough environment for cells to survive in. The centers of solid tumors will become necrotic. They're very low-glucose, low-oxygen environments, a lot of down regulation of T cells. We came at things from that approach and said, 'Are there specific properties of a solid tumor micro-environment that we can arm the T cells to be able to survive better?'" —Geoffrey Hodge, chief executive officer of SOTIO BioTech US

Chimeric antigen receptor (CAR) T-cell therapy has proven to be efficacious for hematological indications, but its utility in solid tumors has been more of a challenge historically.

Many cell therapy developers are exploring combination therapies or secreting cytokines, but SOTIO is taking a different approach, according to Geoffrey Hodge, chief executive officer of SOTIO BioTech US.

"What is it about the solid tumor micro-environment that makes it challenging for T cells? One of the things is that it really is a tough environment for cells to survive in. The centers of solid tumors will become necrotic. They're very low-glucose, low-oxygen environments, a lot of down regulation of T cells," he told CGTL in an interview. "We came at things from that approach and said, 'Are there specific properties of a solid tumor micro-environment that we can arm the T cells to be able to survive better?'"

Hodge and Radek Špíšek, PhD, co-founder and chief executive officer of SOTIO Global, joined CGTL to discuss SOTIO, its 3 technology platforms, its pipeline of IL-15 Superagonists and antibody-drug conjugates, and the status of its clinical programs.

Newsletter

Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.

Recent Videos
Nathan Yozwiak, PhD, the head of research at the GCTI
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira, and Kilian Guse, PhD, the vice president of genetic medicine platforms at Pacira
Derek Jackson, BS, MA, the vice president of cell & gene therapy product development at Pacira
Jeffrey Chamberlain, PhD
Tami John, MD
Tami John, MD
Tami John, MD
Matthew Ku, MBBS, FRACP, RACP, FRCPA/RCPA, PhD, an associate professor and the lymphoma stream lead at St Vincent’s Hospital
Saurabh Dahiya, MD, FACP, an associate professor of medicine at Stanford University School of Medicine; as well as clinical director of Cancer Cell Therapy in the Division of Blood and Marrow Transplantation and Cell Therapy at Stanford Medicine
Shahzad Raza, MD, a hematologist/oncologist at the Cleveland Clinic
Related Content
© 2025 MJH Life Sciences

All rights reserved.