Targeting Unmet Needs in Rare Dermatologic Diseases With Gene Therapy

“Patients with recessive dystrophic EB... from day 1, they need to have constant wound care and are bandaged repeatedly... they have repeated healing and scarring, they lose functionality of their hands, they end up becoming wheelchair bound, and unfortunately, many of them can succumb to squamous cell carcinoma, so they die young. And the cost of wound care is exorbitant... There's a significant unmet need. Any therapy that can reduce the burden of disease and help these wounds heal quicker, so that these patients can live more of a normal life and have a better quality of life is going to be huge.”

REFERENCES

1. Castle Creek Biosciences acquires Novavita Thera to expand innovative cell and gene therapy platform. News release. Castle Creek Biosciences. January 10, 2022. https://castlecreekbio.com/castle-creek-biosciences-acquires-novavita-thera-to-expand-innovative-cell-and-gene-therapy-platform/
2. Castle Creek Biosciences awarded FDA orphan products development grant to support DeFi-RDEB, a pivotal phase 3 study of FCX-007 investigational gene therapy for recessive dystrophic epidermolysis bullosa. News release. Castle Creek Biosciences. October 21, 2021. https://castlecreekbio.com/castle-creek-biosciences-awarded-fda-orphan-products-development-grant-to-support-defi-rdeb-a-pivotal-phase-3-study-of-fcx-007-investigational-gene-therapy-for-recessive-dystrophic-epidermolysis-bull/