|Videos|October 29, 2022
Vlad Hogenhuis, MD, MBA, on Developing Controllable CAR Ts for Solid Tumors
Author(s)Vlad Hogenhuis, MD, MBA
The chief executive officer of Chimera Bioengineering discussed CBIO-007 and its planned IND submission for colorectal and triple negative breast cancer.
Advertisement
"Chimera’s GOLD technology is rooted in the observation that natural T lymphocytes are adept at controlling when and where they produce potent anti-tumor proteins called cytokines. They have discovered important details about how natural T cells control cytokine production, and have used this understanding to design engineered CAR-T cells that produce extremely potent anti-tumor proteins, like Interleukin-12 (IL-12), only upon interaction with a tumor."
Chimera Bioengineering is aiming to address challenges with chimeric antigen receptor (CAR) T-cell therapies with the use of their GOLD platform technology that arms CAR T therapies with immunomodulatory payloads, such as cytokines like interleukin-12.
Chimera is preparing to submit an investigational new drug application (IND) for its lead candidate CBIO-007for the end of 2023 to be able to evaluate the therapy in a phase 1 trial on the east coast. The therapy is targeted toward the tn-mucin1 antigen, and the phase 1 trial will initially evaluate the therapy in colorectal cancer and triple negative breast cancer.
CGTLive spoke with Vlad Hogenhuis, MD, MBA, chief executive officer and board member, Chimera Bioengineering, to learn more about the company and its technologies. He discussed advantages of the GOLD platform as well as preclinical efficacy if CBIO-007 previously observed.
Newsletter
Stay at the forefront of cutting-edge science with CGT—your direct line to expert insights, breakthrough data, and real-time coverage of the latest advancements in cell and gene therapy.
Advertisement
Related Articles
- Around the Helix: Cell and Gene Therapy Company Updates – September 10, 2025
September 10th 2025
- Trends in RNA Therapeutic Research
September 8th 2025
Advertisement
Advertisement
Trending on CGTlive®
1
Patients Treated With REGENXBIO's MPS II Gene Therapy RGX-121 Sustain 82% Median Reduction in CSF HS D2S6 Levels Through 1 Year
2
Around the Helix: Cell and Gene Therapy Company Updates – September 10, 2025
3
Patients With DMD Treated With Avidity Biosciences’ Antibody Oligonucleotide Conjugate Del-Zota Show Functional Improvements
4