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Speakers Suggest Moving Newer Agents Into Earlier Lines in MMBispecific T-cell engagers and chimeric antigen receptor T-cell therapies seem destined to move into earlier lines of therapy for multiple myeloma (MM), speakers at the European Hematology Association 2021 Virtual Congress said.
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Dr. Maloney on the Value of CAR T Cells in Relapsed/Refractory Aggressive LymphomasDavid G. Maloney, MD, PhD, discusses the value of chimeric antigen receptor T-cell therapy in patients with relapsed/refractory aggressive lymphomas.
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Dr. Winter on the Promise of CAR T-Cell Therapy in Hematologic MalignanciesJane N. Winter, MD, professor of medicine, Division of Hematology/Oncology, Northwestern University, discusses the promise of chimeric antigen receptor (CAR) T-cell therapy in hematologic malignancies.
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Monitoring and Support for Patients Receiving CAR T-Cell TherapyExperts discuss providing supportive care to patients receiving CAR T-cell therapy.
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Dr. Daver on CAR T-Cell Therapy Approval in Pediatric ALLNaval Daver, MD, assistant professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the approval of a chimeric antigen receptor (CAR) T-cell therapy in pediatric acute lymphoblastic leukemia.
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Dr. Epperla on CAR T-Cell Therapy in MCLNarendranath Epperla, MBBS, MS, hematologist, The Ohio State University (OSU) Comprehensive Cancer Center, assistant professor in internal medicine, OSU, discusses chimeric antigen receptor (CAR) T-cell therapy for patients with mantle cell lymphoma (MCL).
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Dr. Maloney on Targets for CAR T-Cell TherapyDavid Maloney, MD, PhD, professor of medicine, Division of Oncology, University of Washington, Clinical Research Division, Fred Hutchinson Cancer Research Center, discusses the success and challenges of chimeric antigen recptor (CAR) T-cell therapy in hematologic malignancies.
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Dr. Andreadis on CAR T-Cell Therapy in Relapsed/Refractory MCLCharalambos (Babis) Andreadis, MD, MSCE, discusses the emergence of CAR T-cell therapy in relapsed/refractory mantle cell lymphoma.
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Dr. Berdeja Discusses Response to CAR T-Cell Therapy bb2121Jesus Berdeja, MD, director of Multiple Myeloma Research, Sarah Cannon Research Institute, discusses response to the chimeric antigen receptor (CAR) T-cell therapy bb2121 in patients with multiple myeloma.
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Dr. Coutre Discusses Challenges With CAR T-Cell Therapy in ALLSteven Coutre, MD, professor of medicine at Stanford University Medical Center, discusses challenges with chimeric antigen receptor (CAR) T-cell therapy in acute lymphoblastic leukemia.
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Dr. Perl on Challenges of Implementing Immunotherapy in AMLAlexander E. Perl, MD, MS, discusses the challenges of using immunotherapy with antibody-drug conjugates, bispecific T-cell engagers, and CAR T-cell therapies in acute myeloid leukemia.
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Cilta-Cel Yields High Response Rates in R/R Multiple Myeloma: Saad Z. Usmani, MD, MBA, FACPThe director of Clinical Research in Hematologic Malignancies at Levine Cancer Institute discussed overall response rate and stringent complete responses in the CARTITUDE-1 trial.
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Characteristics, Healthcare Utilization, and Costs of Medicare Patients Receiving CAR T-Cell TherapyKarl M. Kilgore, PhD, senior research scientist, Avalere Health, discusses real-world data regarding Medicare patients with non-Hodgkin lymphoma receiving CAR T-cell therapy.
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Andrew J. Cowan, MD, Discusses the Phase I Clinical Trial of GSI and BCMA CAR T-CellsThe expert explained the rationale for the phase I first-in-human clinical trial evaluating the combination of a gamma-secretase inhibitor and B-cell maturation antigen CAR T-cells in patients with heavily pretreated multiple myeloma.
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Novel CAR T-Cell Therapies to Come From Amgen/Kite Pharma CollaborationAmgen and Kite Pharma have announced that they will collaborate on the development of novel CAR T-cell immunotherapies, with Amgen providing cancer targets and Kite offering its engineered autologous cell therapy platform.
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Dr. Sadelain on CAR T-Cell TherapiesMichel Sadelain, MD, PhD, Director, Center for Cell Engineering and Gene Transfer and Gene Expression Laboratory, Stephen and Barbara Friedman Chair, Memorial Sloan Kettering Cancer Center (MSK), discusses chimeric antigen receptor (CAR) t-cell therapies.
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June Provides Insight Into Managing AEs From CAR T-Cell TherapiesThough clinical work is ongoing and early, researchers are already considering how to manage potentially fatal neurotoxicities in patients treated with chimeric antigen receptor T-cell therapy
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Gene Therapy for Overactive Bladder, Incontinence Shows Good Safety, EfficacyThe locally injected gene therapy product is the subject of an ongoing phase 2a clinical trial.
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KTE-X19 Safe, Efficacious as Therapy for Pediatric B-Cell ALL in ZUMA-4Results of the phase 1 portion of ZUMA-4 support continued investigation into the efficacy of KTE-X19 in pediatric patients with B-cell acute lymphoblastic leukemia.
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Dr. D’Angelo on Selecting CAR T-Cell Therapy or Transplantation in DLBCLChristopher R. D’Angelo, MD, discusses factors that determine whether CAR T-cell therapy or autologous stem cell transplant should be used in patients with relapsed/refractory diffuse large B-cell lymphoma.
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Investigating Strategies to Treat SCD Using Gene TherapyAn expert in hematology/oncology discusses the emerging role of gene therapy to treat sickle cell disease.
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Intravitreal Gene Therapy for Wet AMDAn overview of new gene therapy options for wet AMD that are currently being explored in clinical trials.
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KRd-Autologous Stem Cell Transplant Improves PF Survival in Multiple MyelomaData from the FORTE trial were presented at the 18th International Myeloma Workshop.
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Early Intervention For Neurotoxicity Can Improve Outcomes With Cilta-Cel in Relapsed/Refractory Multiple MyelomaNeurologic adverse effect associated with CAR T-cell therapies like ciltacabtagene autoleucel can be managed without long-term lasting effects, as long as they are caught and treated promptly in patients with relapsed/refractory multiple myeloma.
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Gene Therapy May Improve Vision in XLRP, Further Research NeededSerious adverse events of reduced visual acuity and eye inflammation were observed in 2 clinical trials.
