Breanna DiAndreth, PhD, on Improving Selective Targeting of Tumor Cells

Video

The scientist at A2 Biotherapeutics discussed the company’s dual-receptor Tmod technology.

"Our 2 lead clinical programs right now target carcinoembryonic antigen and mesothelin, which are targets that have been studied before with serious toxicities and adverse events. What we can speculate from this data and what the authors of these clinical trials think is that these are on-target off-tumor toxicities. So, what we could do is bring our blocker in to basically protect those normal tissues.”

Amidst the prevalence of chimeric antigen receptor (CAR) T-cell therapies in indications in hematologic malignancies, solid tumors remain an unmet need that cell therapies have not yet achieved strong responses in. A2 Biotherapeutics is tackling this issue with the use of their dual-receptor Tmod cell therapies that can selectively target tumor cells with HLA-A*02 loss of heterozygosity.

Two lead targets being explored with Tmod cell technology are carcinoembryonic antigen and mesothelin. The therapies are designed to spare healthy tissue expressing these antigens by only attacking tumor cells with the loss of heterozygosity.

Data on the Tmod technology were presented by Breanna DiAndreth, PhD, scientist II, A2 Biotherapeutics at the Onco Cell Therapy Summit (OCTS) USA 2022, held June 29-30 in Boston, Massachusetts. CGTLive spoke with DiAndreth to learn more about the safety advantages of the dual-targeting approach and the technology’s potential to address unmet needs in solid tumors.

REFERENCE
DiAndreth A. The Tmod dual-signal integrator transforms CAR-Ts directed at tumor associated antigens into cancer-selective therapeutics. Presented at: OCTS USA 2022, June 29-30, Boston, MA.
Recent Videos
Lucas Harrington, PhD, the cofounder and chief scientific officer of Mammoth Biosciences
Stephanie Tagliatela on Researching AAV for Lennox-Gastaut, Alzheimer Disease, SCN9a Pain
Miloš Miljković, MD, on mRNA-CAR-T Descartes-08's Potential for Treating Myasthenia Gravis
Manali Kamdar, MD, on Liso-Cel's Ongoing Benefit in the Treatment Lanscape for LBCL
Steve Kanner, PhD, the chief scientific officer of Caribou Biosciences
David Dimmock, MBBS, on AI-Guided ASO Development for Ultra-Rare Diseases
Manali Kamdar, MD, on The Importance of Bringing Liso-Cel to Earlier Lines of Lymphoma Treatment
Subhash Tripathi, PhD, on Generating In Vivo CARs With A2-CAR-CISC EngTreg Cells
Luke Roberts, MBBS, PhD, on Challenges in Developing Gene Therapy for Heart Failure
Steve Kanner, PhD, the chief scientific officer of Caribou Biosciences
© 2024 MJH Life Sciences

All rights reserved.