Personalized Vaccine-Based Therapy for Multiple Myeloma: Nina Shah, MD

Video

The hematologist/oncologist from UCSF Helen Diller Family Comprehensive Cancer Center discussed the potential of vaccine-based therapies in multiple myeloma.

This content originally appeared on our sister site, OncLive.

OncLive spoke with Nina Shah, MD, hematologist and oncologist, associate professor of medicine, Department of Medicine, University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, to learn more about the potential of vaccine-based therapies in multiple myeloma.

Shah discussed how multiple myeloma is characterized by immunosuppression, both in terms of the disease and therapies given. Because of this, vaccine-based treatment approaches may train the immune system to inherently fight the myeloma without the need for additional drugs. Shah cited the phase 2 BMT CTN 1401 study (NCT02728102) in which the patient's plasma cells are fused to dendritic cells, creating a personalized vaccine therapy. The treatment is given after transplant as the immune system is reconstituting, Shah adds.

By giving these vaccines in the setting of lenalidomide (Revlimid), a patient's immune system could be retrained to have T-cell memory against multiple myeloma as these proteins are being presented by dendritic cells that haven't been fused to myeloma cells, Shah continues. The antigens that are being used to train the immune system are unknown, but they are the patient's own antigens, Shah adds.

Moving forward, understanding how durable the effects of vaccine-based approaches are will be important. Additionally, correlative data—some of which suggest that patients have increased T-cell clonality and myeloma-specific T-cell reactivity after multiple cycles of vaccination—could showcase the utility of this therapeutic approach, Shah concludes.

Related Videos
Paula Cannon, PhD, the president elect of ASGCT and a distinguished professor of microbiology at Keck School of Medicine of USC
George Tachas, PhD
Alexandra Gomez-Arteaga, MD
Pietro Genovese, PhD, the principal investigator at the Gene Therapy Program of Dana-Farber/Boston Children’s Cancer and Blood Disorder Center
Akshay Sharma, MBBS, a bone marrow transplant physician at St. Jude Children’s Research Hospital
M. Peter Marinkovich, MD, on Bringing RDEB Treatment to the Local Level
Caspian Oliai, MD, MS, the medical director of the UCLA Bone Marrow Transplantation Stem Cell Processing Center
© 2024 MJH Life Sciences

All rights reserved.