Promising Results on Gene Therapy for Congestive Heart Failure
September 9th 2015California researchers report good results in a phase II study of a gene therapy for congestive heart failure. The news comes five months after Celladon's Mydicar gene therapy for CHF failed to meet its trial's endpoints.
Eltrombopag Approved in Europe for Severe Aplastic Anemia
September 2nd 2015The European Commission has approved eltrombopag as a treatment for adult patients with severe aplastic anemia who are refractory to immunosuppressive therapy or are heavily pretreated and not suitable for hematopoietic stem cell transplant.
Heart Failure Patients: Gene Transfer Therapy Does Not Help
September 1st 2015Barry Greenberg, MD, UCSD Sulpizio Cardiovascular Center, La Jolla, California, USA, presented results from the Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b (CUPID 2) gene transfer study at the European Society of Cardiology 2015 Congress.
Immune Checkpoint Combination Strategies Evolving in NSCLC
August 1st 2015A number of clinical trials are now assessing PD-1 and PD-L1 inhibitors in combination with chemotherapy, targeted therapies, and radiation therapy in an attempt to further improve outcomes for patients with non–small cell lung cancer.
Sonidegib Approved for Advanced Basal Cell Carcinoma
July 29th 2015Oncologists now have a new tool for treating locally advanced basal cell carcinoma. On July 24, 2015, The US Food and Drug Administration (FDA) approved sonidegib (Odomzo) to treat patients with this type of cancer after it has recurred following surgery or radiation therapy.
Advanced Skin Cancer Treatment Approved
July 27th 2015The US Food and Drug Administration recently approved sonidegib (Odomzo/Novartis) to treat patients suffering from locally advanced basal cell carcinoma – the most common form of advanced skin cancer – that had recurred post surgery or radiation therapy.
Study Adds Pembrolizumab to Paradigm for Certain Head and Neck Cancers
July 24th 2015A group of researchers at Washington University in St. Louis recently opened a clinical trial to evaluate pembrolizumab as treatment intensification therapy for patients with high-risk locoregionally advanced, previously untreated, HPV-negative head and neck squamous cell carcinomas.
Dabrafenib/Trametinib Combo Receives Breakthrough Designation for NSCLC
July 23rd 2015The FDA has granted a breakthrough therapy designation to the combination of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib as a potential treatment for patients with BRAFV600E-mutant non-small cell lung cancer.
OncLive's 2015 Giants of Cancer Care Awards Announced
May 30th 2015Twelve of the nation's leading oncology physicians, researchers and academicians were recognized by their peers as the 2015 Giants of Cancer Care at a ceremony hosted by OncLive at the Chicago Illuminating Company last night. The awardees included medical pioneers selected by a panel of eminent oncologists for landmark achievements in translational research, gene therapy, immuno-oncology and other groundbreaking work that has changed the course of cancer treatment.